Oliver Bannach is „Düsseldorf Citizen of the Year 2017“
Oliver Bannach, designated CEO of attyloid, was recently awarded „Düsseldorf Citizen of the Year 2017“ to acknowledge his research on Alzheimer’s disease diagnostics as well as his spin-off activities.
ISO 9001:2015 certification
attyloid announces that its mother institution ICS-6 of Forschungszentrum Jülich has recently obtained ISO 9001:2015 quality certification.
Scientific Background / Technology
Alzheimer’s disease is a neurodegenerative disorder with limited therapeutic and diagnostic options. The failure of late-stage clinical trials has been mainly attributed to a lack of a direct biomarker that can be used for selection of non-symptomatic patients, therapy monitoring, target engagement and outcome measure. Among the most promising biomarker candidates are Aβ oligomers, which are the key players in the disease pathology. We have developed the sFIDA platform technology for ultra- sensitive quantitation of Aβ oligomers in body liquids.
sFIDA stands for surface-based fluorescence intensity distribution analysis. The assay uses a combination of aggregate-binding antibodies and fluorescence microscopy imaging. First, protein aggregates are captured from the sample and fixed to a glass sur- face. After unbound sample components are removed, detection antibodies labeled with two fluorescent dyes are added. A laser focus scans the surface and the highly decorated aggregates show bursts of fluorescent light in two color channels.
In first proof of concept studies, sFIDA allowed clear differentiation between samples from diseased and healthy donors. Moreover, the readout correlated with the severity of cognitive deficits. The assay is currently in the process of validation and optimization for the demands of high-throughput measurements.
ICS-6: Structural Biochemistry
Research at the Forschungszentrum Jülich’s aims for a fundamental understanding of disease-related proteins at the atomic and molecular level. A defining characteristic is the combination of basic research in structural biology and applied research for new diagnostic and therapeutic approaches to neurodegenerative diseases.
High resolution structural biology for molecular biomedicine and biotechnology
- Innovations in diagnostics and therapy for ending Alzheimer’s disease
- Exploring diagnostics and therapy for other prion diseases, e. g. ALS, PD and HD
Forschungszentrum Jülich is located in Jülich about 50 minutes from Düsseldorf Airport and 60 minutes from Düsseldorf City. With over 5,800 employees, Forschungszentrum Julich – a member of the Helmholtz Association – is one of the largest interdisciplinary research centres in Europe, pursuing cutting- edge interdisciplinary research on pressing issues facing society today in the fields of energy and environment, information and brain research.
Heinrich Heine University of Düsseldorf
Heinrich Heine University of Düsseldorf is one of the younger higher education institutions in the state of North Rhine-Westphalia – founded in 1965. Today around 30,000 students study at a modern campus under conditions ideally suited to academic life. The university departments enjoy an excellent reputation due to an exceptionally high number of collaborative research centres.
attyloid draws on a strong team of founders with expertise in Life Science, Health Care and Corporate Development.
Dr. Oliver Bannach
Dr. Andreas Kulawik
Dr. Christian Zafiu
Prof. Dr. Dr. Detlev Riesner
Prof. Dr. Dieter Willbold
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