Recent Study Validates Alzheimer’s Treatment in Beagle Models, Credits sFIDA Technology for Precise Quantification of Tau Aggregates

July 29, 2023

In a significant new study focusing on Alzheimer’s Disease (AD), researchers have highlighted the disease-modifying effects of RD2, a potential treatment for AD. The study specifically evaluated RD2’s impact on enhancing short-term memory and cognition in aged Beagle dogs, serving as a non-transgenic model for the disease. The findings are especially relevant for aging populations, societies, and healthcare systems looking for viable treatments for Alzheimer’s.

A key highlight of the research was the use of surface-based Fluorescence Intensity Distribution Analysis (sFIDA) technology. Known for its high sensitivity and specificity, sFIDA was employed to accurately quantify tau protein aggregates in the cerebrospinal fluid (CSF) of the Beagle models. The precise data captured by sFIDA substantiated the study’s findings, which demonstrated that RD2 significantly reduced cognitive deficits in the models tested, even after the treatment had ended.

The successful use of sFIDA in this study sets a precedent for its indispensable role in pre-clinical models, particularly in the accurate quantification of protein aggregates vital for Alzheimer’s research.

This research brings us a step closer to potentially effective treatments for Alzheimer’s, showcasing the important role that sFIDA technology can play in facilitating reliable and accurate pre-clinical studies.

doi.org/10.1016/j.heliyon.2023.e18443

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